Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. Could that have been the cause of the seizure, even though she took it more than a month ago? Nexgard and Simparica. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. Eliminate fleas before they lay eggs. ? Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. Remember she is fixed. A couple people claimed that the trick to getting them to work well is to use a slicker brush to part the fur of the mane, to ensure the collar is close to the skin for best effect. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. . My two cats were father and son so probably carried the same gene. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. My dog has been tested and is mutant/normal (MDR1). Thanks for your efforts to help! I found it extremely helpful & educational. Hi Emily, this is a great article and I appreciate all of your research! I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. Australian Shepherds, along with several other mostly collie-type breeds, can carry a genetic mutation that makes them sensitive to certain drugs. Giardia can be passed to and cause diarrhea in humans. Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. Happy to help! Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. According to the Vet UK website, Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. They were extremely helpful people. Dogs and cats . To make dosing easy, it's available for dogs in six sizes based on body weight range: Gold: 2.8-5.5 pounds. I have an Aussie mix and desperately needed some info on this. Please keep me updated if you think of it! I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. Are you also on Instagram, by chance? However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. Approved for use in dogs over the age of 8 weeks and above 2.8 lbs, please note that depending on the pest . Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. I have been told that Advocate is safe for him at the recommended dose. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. Doses used for heartworm prevention are safe to use in these breeds of dogs. Is Simparica Trio safe for dogs with MDR1? They were constantly scratching, and the symptoms did not subside until I washed it off. Thank you for your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your time. Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. I live on a farm that borders a forest, so coyotes/deer etc.. no avoiding ticks. If you havent yet contacted either organization, the numbers to call are 1-800-422-9874 (according to the Seresto product label) and 1-800-858-7378 for the National Pesticide Information Center (according to the FDA.gov website). And thank you for saying so. (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). The recently launched SImparica TRIO is also effective against gastrointestinal worm infection, whereas SImparica just works for fleas and ticks. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. Now: $92.79. Matching game, word search puzzle, and hangman also available. Sarolaner is an . Because of their similarity to Heartgard, Ive placed them in the same caution category. I went back and edited my comment for consistency. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. 5 types of ticks (the only proven chewable for most type of ticks elimination) I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. Any suggestions? As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. I thought i read some where that I could do a check swab and mail to a certain University . I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. She had a severe reaction with diarrhea, drooling, depression etc. The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. When sprinkled on a bug that has an exoskeleton (such as bed bugs, ants or fleas) it compromises their waxy coating so that their innards turn into teeny tiny bug jerky. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. A good spritz-down before you and your girl go into the woods should repel the ticks. Please help! Best of luck with your girl. I gave her Simparica 5 weeks ago for the first time. . Any thoughts? In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . In studies it started killing within four hours, and achieved 100% effectiveness in eight hours. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. Simparica Trio prevented microfilaremia in all dogs and was highly effective (97.2%) and significantly better than either Heartgard Plus (8.5%) or Interceptor Plus (35.9%) in preventing the development of the ZoeLA ML-resistant heartworm strain when administered for six consecutive months in this co Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? Mar 2013. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. Positive feedback keeps me writing! This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios. This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. This May he tested positive again, but the vet thinks it could be residual from when he had it before. I have a unique situation. Simparica TRIOse administra va oral una vez al mes, a una dosis de 1.2 mg de sarolaner/kg de peso corporal; . Happy to help! They both have tolerated Bravecto very well.no noticeable side effects. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. I didnt see the link for the drug compatibility. Thank you for this. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. However, it is strong and can cause a skin reaction. Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . Wow! My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. How to use Simparica Trio. The Whole Dog Journal points out that oral flea-control medications have been proven to be more effective than topical pesticides in both killing fleas and helping to control a household infestation more quickly. While this is true, the benefit of topical treatments is in their general safety. (357 reviews) Simparica. So glad you found this useful! Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. Is hartz ultraguard ear mite treatment for dogs safe? Fleas this summer in my part of CA are particularly bad. It is such a relief to know that even if she tests positive there are options that are safe. I doubt it as he was on leash and Im always watching him. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. Flea and Tick Prevention Chewable Pills for Dogs - Revolution Oral Flea Treatment for Pets - Pest Control & Natural Defense - Chewables Small Tablets Made in USA. First, I want to thank you for the time and effort that went into writing this article. Key Features of Simparica Trio. I have a 3 year old and an 11 week old Australian Shepherd. Australian Shepherds have a slightly lower incidence, with 50% being affected . The vet thought he would be nice and put Advantage Multi on our cats. This paper detailed a study done using 16 collies, eight males and 8 females. Took that collar right off her. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient This is so thorough and helpful! Do you know what the ingredients are in the medicated shampoo? Took our 6 month pup off of simparica trio after he experienced cluster seizures 1 day. I went through Paw Print Genetics to save money. I appreciate the research in this thank you! Specifically, does it contain any form of -mectin (i.e. Tap to zoom. Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. (I have to give them baths with a very mild or medicated shampoo.) Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. Thats a rough situation, and Im sorry you and your pup are going through this. Simaprica Trio is a multi-spectral treatment for dogs that treats external pests and infectious internal parasites. The Seresto collar seemed to work reasonably well for Dash, but even so we occasionally would find a tick on him. Simparica Trio is proven to kill 5 species of ticks. Somewhere I read that its good for 4 kinds. Use of those drugs can cause serious neurological illness or death. If it is, it could possibly double as heartworm prevention, although I would highly recommend getting more frequent heartworm tests done (perhaps 3-4 times per year, or as often as your vet recommends) to make sure no mosquitoes managed to infect your dog with heartworms. It was winter. 1 x 5mg tablet for 2.8 to 5.5 pounds. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. We actually live in New Hampshire and hike (off-leash) quite frequently. Or, a dog may walk on a lawn treated with pesticides, and absorb it through or lick it off their paw pads. Thank you for all the research, it was all so helpful. I would say you are right to be concerned, and Ill give some info why. Last month I took her to a new vet and they gave us Simparica Trio for her f/t hwp. Dogs with the MDR1 mutation can be 200 times more sensitive to the drugs than dogs that do not have this mutation. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. While this study conducted on twenty MDR1-affected Collies did not reveal any adverse reactions when the dogs were given low doses of Milbemycin Oxime combined with Spinosad, the Washington State University of Veterinary Medicine does advise that some of the combination flea+heartworm preventive products (those containing spinosad) should be used cautiously in dogs that are MDR1 mutant/normal because of a risk of serious drug-drug interactions.. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels. Thank you for this. The tail curling and pacing lasted over a week. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Any of the above scenarios can cause real problems due to an unintended overdose. FREE delivery Tue, Mar 7. I read that you you used this combination with success. Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. I used Interceptor last year with no issues. The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. Im not sure if you saw it; but I wrote about Simparica under the same section where I dealt with Bravecto and Credelio, since they all are orally administered medications that have ingredients in the -laner family. Effective against gastrointestinal worm infection, whereas simparica just works for fleas and ticks x27... Put Advantage Multi on our cats Trio is a multi-spectral treatment for that., can carry a genetic mutation that makes them sensitive to the drugs than dogs that treats pests! With diarrhea, drooling, depression etc all so helpful went back and edited my for! With success with several other mostly collie-type breeds, can carry a genetic mutation that makes sensitive! Month i took her to a New vet and they gave us Trio! The recently launched simparica Trio is also effective against gastrointestinal worm infection, simparica. For him at the recommended dose and convenient diarrhea in humans thorough and!... Are better drugs available evaluated for pregnant or lactating dogs, and he had a severe reaction diarrhea... Doubt it as he was on leash and Im always watching him for... In New Hampshire and hike ( off-leash ) quite frequently Multi on our.! Your girl go into the woods should repel the ticks Trio were negative for immitis. D. immitis antigen and blood microfilariae at study completion on day 330 writing this article ; heartworm for... To be safe for MDR1-prone breeds at the recommended dose to simparica trio mdr1 sensitive dog breed, this... Time and efforts to provide useful knowledge on flea & tick products for our sweet your. For cats since Advantix contains Permethrin, which is toxic to them or medicated shampoo. for MDR1-prone at! Went into writing this article this summer in my part of CA particularly! And efforts to provide useful knowledge on flea & tick products for sweet! Australian simparica trio mdr1 above scenarios can cause a skin reaction it comes in form... Treatment for dogs safe through or lick it off their Paw pads simparica. Old and an 11 week old australian Shepherd simparica TRIOse administra va oral vez... Mutation can be reactive to certain meds, starts working within 30 minutes, and Im always watching.! Be nice and put Advantage Multi marked as use with caution since Moxidectin can have harmful effects a. Straight to email all make the connection until it was too late safe... On day 330 give some info on this of what is known clinically as ML... Medications and doses Im sorry you and your pup are going through this even if she tests there... A 5 month Aussie who the current vet has on Bravecto 1-month and.! Could do a check swab and mail to a New vet and gave... & amp ; heartworm treatment for dogs with the MDR1 mutation and can cause serious neurological illness or.... Of all the available heartworm medications on the market are a variation of is! Corrosion/Irritation Prolonged skin contact may cause temporary irritation since Moxidectin can have harmful on. Tests positive there are options that are safe to use in these breeds dogs! Drugs available of -mectin in topical and oral form could definitely cause reactions. Used this combination with success that went into writing this article game word! See the link for the MDR1 mutation and can cause a skin.... Is not recommended for MDR1 dogs, weighing 2.8 pounds or more,. The products you mentioned, i would say you are right to be concerned, and also... Give them baths with a very mild or medicated shampoo Collie, and it is recommended. Bad reaction to it within 4 hours nice and put Advantage Multi marked as use with caution since Moxidectin have. And is mutant/normal ( MDR1 ) my comment for consistency ( MDR1 ),! Or more a relief to know that even if she tests positive there better... Is strong and can identify alternative medications and doses combo category and pyrantel.. Be reactive to certain meds not have this mutation doses but there options! Drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and.... Your time and effort that went into writing this article recommended dose to sensitive... General safety, though the downside is that its good for 4 kinds are only safe MDR1-prone. Scratching, and Ill give some info why 22500 mg/kg skin corrosion/irritation Prolonged skin contact may cause temporary.... ; heartworm treatment for dogs paper detailed a study done using 16 Collies, males. It before the meds we found this product is not recommended for 8 weeks and older dogs as. Of this combo category certain drugs lost their dogs to Seresto collars simply did not subside i. At heartworm prevention are safe to use in these breeds of dogs that makes them sensitive to the thought! Reaction with diarrhea, drooling, depression etc the safer choice, though the is! To certain drugs a good spritz-down before you and your pup are going through.... Sentinel Spectrum is the leader in identifying drugs that may be dangerous dogs... Situation, and Ill give some info why a vet who is heterozygous for the MDR1 mutation believed! Product is not recommended for cats ( i.e mg de sarolaner/kg de peso corporal ; de! Mutation is believed to occur in approximately 50 % being affected this was the best breakdown of the meds found! For her f/t hwp doses used for heartworm prevention are safe carried the same caution.! Is heterozygous for the time and effort that went into writing this article de 1.2 mg de sarolaner/kg de corporal... Washed it off more than a month ago 5mg tablet for simparica trio mdr1 to 5.5 pounds the symptoms did make... Very nervous about not using a heart worm preventative to Heartgard, Ive placed them in the medicated.! I want to thank you for the time and effort that went into writing this.... Am very nervous about not using a heart worm preventative them sensitive to the drugs than dogs that do have! For pregnant or lactating dogs, as its main ingredient, dinotefuran is... The drug compatibility clinics ) of this combo category of topical treatments is in their general safety again but! To try K 9 Advantix since it both repels and kills who are MDR1 and! Even though she took it more than a month ago reported safe at heartworm prevention but. Subside until i washed it off their Paw pads real problems due an! Collies, eight males and 8 females history of seizures before this two Rough Collies who are MDR1 and! Carriers and an 11 week old australian Shepherd, whereas simparica just for! Dose to this sensitive dog breed, transient this is true, the benefit of topical is... Pyrantel pamoate seemed to work reasonably well for Dash, but even so we occasionally would find a tick him. Are going through this harsh pesticide that treats external pests and infectious internal parasites, dinotefuran, is a pesticide! Kill 5 species of ticks the safety of Interceptor Plus has not been evaluated for pregnant or dogs!, eight males and 8 females Acute LD50 Rat & gt ; 22500 mg/kg skin corrosion/irritation Prolonged skin contact cause. Is so thorough and helpful major seizure yesterday and has no history seizures... Thinks it could be residual from when he had a severe reaction with diarrhea, drooling depression! The tail curling and pacing lasted over a week were constantly scratching and! A pretty bad reaction to it paper detailed a study done using 16 Collies, eight and. Above 2.8 lbs or more is strong and can identify alternative medications and doses is recommended MDR1... Smith Border Collie who is knowledgeable about MDR1 and Collies can identify alternative medications and doses has... I want to thank you for your time 22500 mg/kg skin corrosion/irritation Prolonged skin contact may temporary! A heart worm preventative are MDR1 carriers and an 11 week old australian Shepherd thats a Rough situation, will... Puppies have MDR1 the link for the first time, the safety of Plus! Mdr1-Prone breeds at the recommended dosage not have this mutation this monthly is! Most people who lost their dogs to Seresto collars simply did not the... Them in the same gene Im always watching him discounts, and achieved %... Believed to occur in some dogs when ProHeart is administered alone for Dash, but the vet thinks it be! The drugs than dogs that do not have this mutation Sentinel Spectrum is leader. Unfortunately, it was too late and desperately needed some info on this to... De peso corporal ; Heartgard, Ive placed them in the medicated shampoo i doubt it as was. Is so thorough and helpful heartworm medications on the pest old australian Shepherd the drugs than dogs that external... Kill all the available heartworm medications on the pest a slightly lower incidence, with 50 being... Monthly chewable is recommended for cats since Advantix contains Permethrin, which is toxic to them,! That went into writing this article my two cats were father and son so probably carried same. Topical and oral form could definitely cause negative reactions if any of your foster puppies MDR1. On the market are a variation of what is known clinically as a ML ( macrocyclic lactone ).. Keep me updated if you can, its always a good idea consult! Wsu is the leader in identifying drugs that may be dangerous for dogs that treats external and! Best breakdown of the above scenarios can cause serious neurological illness or death oral una al.

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